27th April 2021
Robert Graham, the Deputy Director of the Stoller Biomarker Discovery Centre at the University of Manchester, shares why the SBDC chose PEAK's Genius nitrogen generator for their biomarker discovery.
In its present form, the University of Manchester was created in 2004 by the union of the Victoria University of Manchester and the University of Manchester Institute of Science and Technology. After one hundred years working closely together both institutions agreed to form a single university and, on 22nd October 2004, they officially combined to form the largest single-site university in the UK.
The Stoller Biomarker Discovery Centre, located within the University of Manchester, aims to identify biomarkers that could be used to diagnose or inform treatment of diseases such as cancer and arthritis. They aim to find protein markers in the blood that could be used to stop patients being given treatments which won’t improve their condition. These markers will be developed to ensure doctors can prescribe the right treatment for the right patient as early as possible.
The research will boost work led by the University of Manchester to identify new biomarkers for response to therapy in diseases such as rheumatoid arthritis, systemic lupus erythematosus, Alzheimer’s disease and psoriasis.
Typically what is the focus of your LC-MS analysis – what sort of applications?
Our LC-MS analysis focuses on biomarker discovery.
What PEAK Scientific generators do you have in your laboratory and what LC-MS instruments do they supply?
We use the Genius ABN2ZA which supplies a SCIEX TripleTOF 5600.
What prompted you to choose a PEAK generator and how long have you used them?
I have used them before in previous labs and been using them at SBDC for six years.
What has been the key benefit of deploying PEAK generators as opposed to your previous gas supply solution?
The main benefit I have found is the ease of use of the generators.
How would you describe your purchasing experience with PEAK in terms of speed of response, ease of ordering, catering to your needs and timing of delivery?
My purchasing experience has been very good through all stages of the process.
Have you ever had a site visit from a PEAK engineer, if so, could you describe your experience of this support?
Yes I’ve had several engineer visits and they are always efficient and cause minimum disruption.
Would you recommend PEAK Scientific generators to other laboratories – and if so, what would be your main reason for the recommendation?
I would recommend them. They are efficient, the generators are reliable, and the support is excellent.
Designed to cater for the requirements of the SCIEX range of LC-MS instruments, the Genius ABN2ZA is a nitrogen generator which provides one source of Nitrogen gas and two independent supplies of clean, dry air specifically to support SCIEX instruments.
With the ABN2ZA based on proven technology, it removes oxygen, moisture and other gases to leave clean, dry, phthalate free Nitrogen and Dry Air. Two internal air compressors make this unit independent from in-house air supplies and fitted castors allow the user to easily position the unit in the lab.
One of the key recommendations Robert would give to others is that of our after-sales support services. This is a key point that sets PEAK apart from other gas generator suppliers; our world-class after-sales care.
We pride ourselves on our ability to provide quality, rapid response service across the globe. Our global team of dedicated Field Service Engineers are trained by PEAK Scientific. This means they gain exclusive technical knowledge of our gas generators which results in a smooth installation as well as efficient maintenance and repair, with a 95% first fix rate. At PEAK, we also offer a range of [Peak Protected] service plans providing a selection of options for you to choose from, depending on your requirements. These can minimize downtime in your lab through plans such as the Complete Plan 72 and Complete Plan 48, in some regions, which offer a guaranteed global response time of 72 hours and 48 hours respectively.
While the Genius ABN2ZA that the team at the University of Manchester use is now discontinued, we have upgraded the product with the Genius XE SCI 2 or the Genius 1024, depending on the specific SCIEX LC-MS instrument your lab uses. Both products were developed exclusively to meet the specific needs of SCIEX instruments. The Genius XE SCI2 was developed with SCIEX for the very latest in their mass spectrometer technologies, the Echo MS System and SCIEX Triple Quad 7500 LC-MS System, and is the only approved gas generator solution for the two instruments. The Genius 1024 was designed exclusively to meet the needs of SCIEX LC-MS systems and is approved by SCIEX for use with their Research Use Only LC-MS systems.
Looking for a nitrogen generator for your lab?
Nitrogen for LC-MS is what we are best known for. Our first nitrogen generator, produced over 20 years ago, supplied an LC-MS instrument and since then we have become experts in LC-MS nitrogen gas generators, developing solutions for the world's leading analytical instrument manufacturers.