12th December 2017

How to speed up your gas chromatography


Read our quick tips on how you could speed up your GC analysis. The effectiveness and opportunity to implement these will be dependent upon the analysis you are running. 

We shares 4 ways to help streamline your GC workflow.

Speed up gas chromatography

4 ways to speed up
Gas Chromatography

without having to upgrade your system.

Implementing techniques to speed up GC is an effective way to streamline your workflow. Research has shown many techniques which if all implemented can reduce run times by up to ten times that of a conventional GC, although this can have an impact on resolution which must be taken into consideration before implementation. Nevertheless, finding the time for GC techniques such as method optimization can be challenging. Here we present four simple ways to reduce analysis time on your GC set up. Whilst these do require a little time to implement, your lab can reap rewards quickly.
Use a shorter column to speed up gas chromatography

Use a shorter column

By reducing the length of your capillary column, you can shorten analysis times considerably, even when running the carrier gas at the same linear velocity. Oven programs will be faster, meaning the maximum temperature is reached more quickly. Separation can be slightly affected, so be careful of co-elution.  
Use hydrogen to speed up you gas chromatography

Use a faster carrier gas

  Hydrogen is half as viscous as helium, making it about twice as fast at the same temperature and pressure meaning significantly faster separations. The great thing about hydrogen is that you can safely make it in the laboratory using a hydrogen generator, offering a cheap gas solution. Hydrogen has better efficiency than helium at higher linear velocities so your sample will separate well, even at high flow rates.
Use a smaller diameter capillary to speed up you gas chromatography

Use a smaller diameter capillary

Working on a very similar principle as a shorter column, replacing a 30 m × 0.25-mm capillary with a 20 m × 0.15- mm capillary can reduce run times by a factor of 2, this should provide the same efficiency when using the same carrier gas.  
A different temperature program can speed up your gas chromatography results

A different temperature program

  With a faster oven program rate, you will see quicker elution with a far more compact show of peaks in your results. Though the elution temperature of components may result in different peak separations during this process, increasing the analysis temperature for an isothermal analysis will decrease analysis time. This may result in some loss of resolution, but only if the temperature is increased too fast for your analysis.

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