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Method implications on lab gas supply for Residual Solvent Analysis using HS-GC-FID - as featured in The European Pharmaceutical Manufacturer Magazine.
The Precision generator range has been designed to produce ultra-high purity (UHP) gases to supply GC applications for carrier and detector gas supply.
Background Researchers from Prof. Guido Verbeck’s group at the University of North Texas (UNT) carried out analysis of drugs of abuse (DOA) and explosives using an ion trap GC-MS to compare results when using helium and hydrogen carrier and buffer gas. As well as comparing the two gases, the group also assessed a number of ion volumes with different orifice diameters to look at their effect on sensitivity with either gas.
Results are used in court to provide quantitive levels of BAC, which makes it one of the most commonly practised analyses in forensic laboratories. The large number of samples and requirement for speed of sample processing mean that analysis needs to be conducted quickly, whilst giving reliable and accurate results.
Changing carrier gas from helium to hydrogen does not always present an opportunity for faster sample analysis. Method revalidation can be simplified by keeping the new method as close to the old method as possible, which will limit changes to sample selectivity and resolution whilst maintaining the retention times of analytes.