Your local gas generation partner

Menu

What are Evaporative Light-Scattering Detectors?

Evaporative Light-Scattering Detectors (ELSDs) are used to facilitate High-Performance Liquid Chromatography (HPLC).

Refractive Index (RI) Detectors are also used for HPLC but with less success as they are easily affected by changes in ambient temperature, and cannot always detect target substances with short elution times. ELSDs, which have been growing in popularity since the 1980s, solve these problems and do not require time for the instrument and baseline to stabilise.

ELSD Instruments

Evaporative Light-Scattering Detectors

ELSDs are aerosol-based HPLC detectors which work by converting the eluents of target components (carried by an inert carrier gas such as Nitrogen) to a fine spray via a nebulizer. This spray is then heated so that only the mobile phase evaporates. Light is then focused on the remaining target substance and scattered light is detected. The primary advantage for researchers using ELSD is that, unlike spectroscopic detectors, it can identify samples which cannot be found using UV detection methods such as carbohydrates, sugar alcohols surfactants and natural synthetic molecules.

There are many applications for ELSD as it is one of the most universal detectors available for HPLC. It is commonly used for carbohydrate, lipid and polymer analysis but can also be used in a variety of other applications. ELSD is an ideal detector for drug discovery, combinatorial chemistry, and the analysis of natural substances.

An ELSD requires a supply of clean, dry (preferably inert) gas and the Solaris Nitrogen generator meets this need. The Solaris Nitrogen generator provides a gas solution for ELSD which can help labs who are optimizing ELSD and their lab analysis in general. Solaris is a dedicated solution which offers the nitrogen gas flow and purity required for ELSD whilst removing the inconvenience, hassle and safety concerns which are inherent with cylinder gas supply.

Solaris Nitrogen Generator and stackable air compressor

The Solaris Nitrogen Generator and Solaris Air Compressor

Sources

http://www.usedhplc.co.uk/UsedHPLC-IntroductiontoEvaporativeLightScatteringDetectorsELSD.htm

http://www.genengnews.com/gen-articles/achieving-precision-analysis-with-elsd/2554?kwrd=Shimadzu%20Scientific%20Instruments

http://images.alfresco.advanstar.com/alfresco_images/pharma/2014/08/22/b5466473-7477-491f-93d3-e208b883f3c9/article-47198.pdf

Post a comment

Please enter the code as shown:

Comments

No Comments

Tags

USA Missouri Scotland China Sample Preparation Nitrogen GC Precision Thermo Scientific Geneva Toxicology Zero Air Hydrogen Africa Sweden Malmo Japan Austria Mass Spectrometer Medical Birmingham Mass Spectrometry Helium Glasgow United Kingdom Beijing Nitrogen Hydrogen Agilent Barcelona Spain Melbourne Australia LC-MS India Mumbai South Africa Quality California pancake science Proteomics show valentines love Price increase bulk gas Peak Scientific Gas Chromatography Academia Sciex sciex nitrogen tour hydrogen Award Gas Generator Innovation Queen's Award on-site adsorption PSA safety cylinders lab gas on-site nitrogen generation CMS Analytica Germany gas generators exhibitions Munich Genius 3010 laboratory analysis Ant Teknik Eurasia Istanbul Turkey Hydrogen trace nitrogen trace careers football GC-MS food quality Genius Shimadzu 3051 Peak Kemiportalen pairing search find gas generation Sweat diffusion through snow GC analysis Gas chromatography capillary column gas generator cylinder AZOM MRX labs gas chromatography wine cork no-taint Amorim NDtech jobs cancer dogs Infinity showcase product elements Nihonium Moscovium Tennessine Oganesson The International Union of Pure and Applied Chemistry Carrier Gas Tomatoes La Tomatina Chromatography today gas cylinder BioTechniques User Manuals generator Stoller Biomarker Discovery Centre MS table Mass Spec Thermal Desorption Sampling Corona CAD Detector JASIS Dusty Singapore training Solaris china precision nm32la agilent (MSACL) conference service Protected lab proteomics peak protected NMR spectroscopy Tianjin Ionization Mass Spectrometry Conference AIMS 2016 high-purity gas After-sales maintenance seminar Genius series LCMs Genius Nitrogen Generator Precision Hydrogen Generator maintenance ELSD Micro Mass Spec zero air i-FlowLab whole of lab HPLC register flexflow elsd solaris mass spec high-performance liquid chromatography N2 Solaris Nitrogen Northern Flicker bird Tartarian Morrow's Honeysuckle APS Proteomics Lorne exhibition FlexFlow helium Valentine's Day mass spectrometry hydrogen generator nitrogen generator chromatography customer service expertise warranty hplc Europe gas food gc lcms carrier gas daisy chain gc-ms China-lab GCMS zeroair iflow Peak SCientific TOC LC-MS Chromatography Gas generators asms launch reviews NM32LA genius selectscience asia oil & gas n2 oxygen ICP-MS collision Qatar Select Science Complete Protected generators event university singapore Cylinders switch design technology Scientific Exhibition show after service support engineer OEM chromatographie Values brand promise protected CPL-SM Aerosol detector Cannabis Quality Control Testing LCMS SM-PCI hydrogène gaz de collision Garantie générateur de gaz Gasgenerator Nitroge iflow lab Careers Recruitment Sample Evaporation ICP CO2 Analyzer FT-IR TOC hygrogen i-flowlab azote LC_MS
To Top
Close