Your local gas generation partner


How to speed up your gas chromatography

We shares 4 ways to help streamline your GC workflow.

Speed up gas chromatography

4 ways to speed up
Gas Chromatography

without having to upgrade your system.

Implementing techniques to speed up GC is an effective way to streamline your workflow. Research has shown many techniques which if all implemented can reduce run times by up to ten times that of a conventional GC, although this can have an impact on resolution which must be taken into consideration before implementation. Nevertheless, finding the time for GC techniques such as method optimization can be challenging. Here we present four simple ways to reduce analysis time on your GC set up. Whilst these do require a little time to implement, your lab can reap rewards quickly.
Use a shorter column to speed up gas chromatography

Use a shorter column

By reducing the length of your capillary column, you can shorten analysis times considerably, even when running the carrier gas at the same linear velocity. Oven programs will be faster, meaning the maximum temperature is reached more quickly. Separation can be slightly affected, so be careful of co-elution.
Use hydrogen to speed up you gas chromatography

Use a faster carrier gas

Hydrogen is half as viscous as helium, making it about twice as fast at the same temperature and pressure meaning significantly faster separations. The great thing about hydrogen is that you can safely make it in the laboratory using a hydrogen generator, offering a cheap gas solution. Hydrogen has better efficiency than helium at higher linear velocities so your sample will separate well, even at high flow rates.
Use a smaller diameter capillary to speed up you gas chromatography

Use a smaller diameter capillary

Working on a very similar principle as a shorter column, replacing a 30 m × 0.25-mm capillary with a 20 m × 0.15- mm capillary can reduce run times by a factor of 2, this should provide the same efficiency when using the same carrier gas.  
A different temperature program can speed up your gas chromatography results

A different temperature program

With a faster oven program rate, you will see quicker elution with a far more compact show of peaks in your results. Though the elution temperature of components may result in different peak separations during this process, increasing the analysis temperature for an isothermal analysis will decrease analysis time. This may result in some loss of resolution, but only if the temperature is increased too fast for your analysis.

Download PDF Version | Download JPG Version

Post a comment

Please enter the code as shown:


Martin George - 31/01/2018 06:14
Dear Sirs,
I would like to ask your advice that I’v changed the carrier gas to Nitrogen generator in my RGA Gas chromatography SCION 456 , would it give me the same resolution and efficiency as helium,? please be informed that the company preconfigured our GC carrier gas as Helium . Your reply is highly appreciated.
Ed Connor - 31/01/2018 09:41
Hi Martin,

If you are loooking to change from helium to nitrogen carrier gas, you can use this tool from Restek: to check the instrument parameters you need to optimise your efficiency. This work (also by Restek) shows how you can change the column dimensions to get like-for-like results. You may need to optimise your split flow, but the info there should help you get similar results to your helium method.

Please let us know how you get on, and if you need a generator, you know where to come!

Best regards,


Peak Scientific ASMS conference Peak Scientific scoops Scottish Exporter of the Year Award Scottish Engineering Awards Nitrogen Trace Product Catalogue HPLC Geneva International Track Fastest Growing Private Business Gas Chromatography Nitrogen Carrier Gas Hydrogen cylinders Dr Ed Connor Awards JASIS Japan Precision video GC Austria (MSACL) conference Birmingham Helium gas agilent generator celebrate gas agilent tardis peak Dusty Beijing Nitrogen Hydrogen ebf gas generation #dustyontour lab gas nitrogen hydrogen China #dustyontour Melbourne laboratory Peak logo Matterhorn LC-MS gas generator analysis laboratory gas generator modified atmosphere packaging laser cutting electronic component assembly India Exhibition lab National Convention South African Chemical Institute SACI lab gas bottling sparging flushing storing wine Christmas 12 days Rudolph christmas xmas new periodic elements song music universe generation Scotland pancake science Australia Proteomics show valentines love Price increase bulk gas Agilent Safety Mass Spectrometry Sciex sciex tour Award Gas Generator Innovation Queen's Award on-site adsorption PSA safety on-site nitrogen generation CMS Analytica Germany gas generators exhibitions Munich Genius 3010 Ant Teknik Eurasia Istanbul Turkey Hydrogen trace nitrogen trace careers football GC-MS food quality Genius Shimadzu 3051 Kemiportalen pairing search find Sweat diffusion through snow GC analysis Gas chromatography capillary column cylinder AZOM MRX labs gas chromatography wine cork no-taint Amorim NDtech jobs cancer dogs Infinity showcase product Nihonium Moscovium Tennessine Oganesson The International Union of Pure and Applied Chemistry Tomatoes La Tomatina Chromatography today gas cylinder BioTechniques User Manuals Stoller Biomarker Discovery Centre MS table Mass Spec Thermal Desorption Sampling Corona CAD Detector Singapore training Solaris china precision nm32la service Protected proteomics peak protected NMR spectroscopy Tianjin Ionization Mass Spectrometry Conference AIMS 2016 high-purity gas After-sales maintenance seminar Genius series LCMs Genius Nitrogen Generator Precision Hydrogen Generator maintenance ELSD Micro Mass Spec zero air i-FlowLab whole of lab register flexflow elsd solaris mass spec high-performance liquid chromatography N2 Solaris Nitrogen Northern Flicker bird Tartarian Morrow's Honeysuckle APS Proteomics Lorne exhibition FlexFlow helium Valentine's Day mass spectrometry hydrogen generator nitrogen generator chromatography customer service expertise warranty hplc Europe food gc lcms gc-ms China-lab GCMS zeroair iflow Peak SCientific TOC LC-MS Chromatography Gas generators asms launch reviews NM32LA genius selectscience asia oil & gas n2 oxygen ICP-MS collision Qatar Select Science Complete Protected generators event university singapore USA Cylinders switch design technology Scientific show after service support engineer OEM chromatographie Values brand promise protected CPL-SM Thermo Scientific Aerosol detector Cannabis Quality Control Testing LCMS SM-PCI hydrogène gaz de collision Garantie générateur de gaz Gasgenerator Nitroge iflow lab Careers Recruitment Sample Evaporation ICP CO2 Analyzer FT-IR TOC hygrogen carrier gas i-flowlab azote LC_MS
To Top