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GC-MS used successfully to identify bladder cancer from urine headspace

Bladder cancer is one of the most common cancers in the UK and a group of scientists have experimented with a new non-invasive way to potentially diagnose it in the future.

As studies have previously indicated that volatile organic compounds specific to bladder cancer may exist in urine headspace, scientists have decided to research this further by analysing urine samples from two goups;  patients diagnosed with bladder cancer or a non-cancerous urological disease or infection, and from healthy volunteers.


Outline of the human bladder

The volatile metabolomes in the urine headspace were analysed using Gas Chromatography Mass Spectrometry (GC-MS)  and a specifically designed pattern recognition system was found to be 89% accurate at making diagnoses of the samples. This result provides further evidence of the potential for volatile biomarkers to form the basis of a non-invasive diagnostic technique for bladder cancer.

The analytical method used in this research, GC-MS, often requires a carrier gas such as hydrogen.  If you require carrier gas for GC-MS, or gas for any other laboratory applications such as ELSD, LCMS, GC or TOC, you can find your ideal gas generator here on the Peak Scientific website.

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Evaluation of gas chromatography mass spectrometry and pattern recognition for the identification of bladder cancer from urine headspace

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